Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update From the GBD 2019 Study

GA Roth; GA Mensah; CO Johnson; G Addolorato; E Ammirati; LM Baddour; NC Barengo; A Beaton; EJ Benjamin; CP Benziger; A Bonny; M Brauer; M Brodmann; TJ Cahill; JR Carapetis; AL Catapano; S Chugh; LT Cooper; J Coresh; MH Criqui; NK DeCleene; KA Eagle; S Emmons-Bell; VL Feigin; J Fernández-Sola; FGR Fowkes; E Gakidou; SM Grundy; FJ He; G Howard; F Hu; L Inker; G Karthikeyan; NJ Kassebaum; WJ Koroshetz; C Lavie; D Lloyd-Jones; HS Lu; A Mirijello; AT Misganaw; AH Mokdad; AE Moran; P Muntner; J Narula; B Neal; M Ntsekhe; GMM Oliveira; CM Otto; MO Owolabi; M Pratt; S Rajagopalan; MB Reitsma; ALP Ribeiro; NA Rigotti; A Rodgers; CA Sable; SS Shakil; K Sliwa; BA Stark; J Sundström; P Timpel; II Tleyjeh; M Valgimigli; T Vos; PK Whelton; M Yacoub; LJ Zuhlke; M Abbasi-Kangevari; A Abdi; A Abedi; V Aboyans; WA Abrha; E Abu-Gharbieh; AI Abushouk; D Acharya; T Adair; OM Adebayo; Z Ademi; SM Advani; K Afshari; A Afshin; G Agarwal; P Agasthi; S Ahmad; S Ahmadi; MB Ahmed; B Aji; Y Akalu; W Akande-Sholabi; A Aklilu; CJ Akunna; F Alahdab; A Al-Eyadhy; KF Alhabib; SM Alif; V Alipour; SM Aljunid; F Alla; A Almasi-Hashiani; S Almustanyir

Journal article

Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update From the GBD 2019 Study

GA Roth, GA Mensah, CO Johnson, G Addolorato, E Ammirati, LM Baddour, NC Barengo, A Beaton, EJ Benjamin, CP Benziger, A Bonny, M Brauer, M Brodmann, TJ Cahill, JR Carapetis, AL Catapano, S Chugh, LT Cooper, J Coresh, MH Criqui Show all

Journal of the American College of Cardiology | Published : 2020

DOI: 10.1016/j.jacc.2020.11.010

Abstract

Cardiovascular diseases (CVDs), principally ischemic heart disease (IHD) and stroke, are the leading cause of global mortality and a major contributor to disability. This paper reviews the magnitude of total CVD burden, including 13 underlying causes of cardiovascular death and 9 related risk factors, using estimates from the Global Burden of Disease (GBD) Study 2019. GBD, an ongoing multinational collaboration to provide comparable and consistent estimates of population health over time, used all available population-level data sources on incidence, prevalence, case fatality, mortality, and health risks to produce estimates for 204 countries and territories from 1990 to 2019. Prevalent case..

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University of Melbourne Researchers

Timothy Adair Author

Sheikh Alif Author

Robert Weintraub Author

Nuruzzaman Khan Author

Grants

Awarded by National Institutes of Health

Funding Acknowledgements

This study was funded by the Bill and Melinda Gates Foundation. Dr. Benjamin has received funding from the National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (NHLBI) (R01HL092577, 1R01HL128914) and American Heart Association (18SFRN34110082). Dr. Brauer has received a grant from the Bill and Melinda Gates Foundation. Dr. Catapano has received support from Fondazione Cariplo 2015-0524 and 2015-0564, H2020 REPROGRAM PHC-03-2015/667837-2, ERA NET ER-2017-2364981, GR-201102346974, Ministry of Health -Ricerca Corrente Multimedica; has received research grant/support from Sanofi, Sanofi Regeneron, Amgen, Mylan, Menarini, and Eli Lilly; has served on the speakers bureau for Akcea, Amgen, Sanofi, Esperion, Kowa, Novartis, Ionis Pharmaceuticals, Mylan, Menarini, Merck, Recordati, Regeneron, Daiichi-Sankyo, AstraZeneca, Aegerion, Amryt, and Sandoz; has received honoraria from Akcea, Amgen, Sanofi, Esperion, Kowa, Novartis, Ionis Pharmaceuticals, Mylan, Menarini, Merck, Recordati, Regeneron Daiichi-Sankyo, AstraZeneca, Aegerion, Amryt, and Sandoz; and has served as a consultant/on the Advisory Board for Akcea, Amgen, Sanofi, Esperion, Kowa, Novartis, Ionis Pharmaceuticals, Mylan, Menarini, Merck, Recordati, Regeneron Daiichi-Sankyo, Genzyme, Aegerion, and Sandoz. Dr. Coresh has received funding from the NIH and National Kidney Foundation; and has served as an advisor to Healthy.io. Dr. Fowkes has served on the Advisory Board for AstraZeneca. Dr. Muntner has received grants and personal fees from Amgen Inc. Dr. Ribeiro has received partial support by CNPq (310679/2016-8 and 465518/2014-1) and by FAPEMIG (PPM-00428-17). Dr. Zuhlke has received funding by the UK Medical Research Council (MRC) and the UK Department for International Development (DFID) under the MRC/DFID Concordat agreement and the National Research Foundation of South Africa. Dr. Rigotti has served as a consultant to Achieve Life Sciences; and has received royalties from UpToDate, Inc. Dr. Rodgers is employed by The George Institute for Global Health (TGI) and seconded part time to George Medicines Pty Ltd (GM); TGI has submitted patent applications with respect to low-fixed-dose combination products for the treatment of cardiovascular or cardiometabolic disease and is listed as one of the inventors; George Health Enterprises Pty. Ltd. (GHE) and its subsidiary, GM, have received investment funds to develop fixed-dose combination products, including combinations of blood pressure-lowering drugs; GHE is the social enterprise arm of TGI (Dr. Rodgers does not have a direct financial interest in these patent applications or investments). Dr. Sundstrom holds ownership in companies providing services to Itrim, Amgen, Janssen, Novo Nordisk, Eli Lilly, Boehringer Ingelheim, Bayer, Pfizer, and AstraZeneca, outside the submitted work. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.