Are Mycoplasma hominis, Ureaplasma urealyticum and Ureaplasma parvum Associated with Specific Genital Symptoms and Clinical Signs in Nonpregnant Women?

EL Plummer; LA Vodstrcil; K Bodiyabadu; GL Murray; M Doyle; RL Latimer; CK Fairley; M Payne; EPF Chow; SM Garland; CS Bradshaw

Journal article

Are Mycoplasma hominis, Ureaplasma urealyticum and Ureaplasma parvum Associated with Specific Genital Symptoms and Clinical Signs in Nonpregnant Women?

EL Plummer, LA Vodstrcil, K Bodiyabadu, GL Murray, M Doyle, RL Latimer, CK Fairley, M Payne, EPF Chow, SM Garland, CS Bradshaw

Clinical Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2021

DOI: 10.1093/cid/ciab061

Abstract

Background: There is limited evidence supporting an association between Mycoplasma hominis, Ureaplasma urealyticum, and Ureaplasma parvum with symptoms or disease in nonpregnant women. However, testing and reporting of these organisms frequently occurs, in part due to their inclusion in multiplex-PCR assays for sexually transmitted infection (STI) detection. We investigated if M. hominis, U. urealyticum, and U. parvum were associated with symptoms and/or signs in nonpregnant women attending a sexual health service. Methods: Eligible women attending the Melbourne Sexual Health Centre completed a questionnaire regarding sexual practices and symptoms. Symptomatic women underwent examination. Wo..

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University of Melbourne Researchers

Erica Plummer Author

Lenka Vodstrcil Author

Kaveesha Bodiyabadu Author

Gerald Murray Author

Grants

Awarded by Australian NHMRC Leadership Investigator Grant

Awarded by Australian NHMRC Emerging Leadership Investigator Grant

Awarded by NHMRC

Funding Acknowledgements

This work was supported by a Victorian Medical Research Acceleration Fund (including salary support for K. B.). Melbourne Sexual Health Centre received funding from SpeeDx Pty Ltd (Australia) in support of this research project. SpeeDx provided diagnostic kits for testing. E. L. P. and R. L. L. were supported by an Australian Government Research Training Program (RTP) Scholarship. C. S. B. and C. K. F. are supported by an Australian NHMRC Leadership Investigator Grant (GNT1173361 and GNT1172900, respectively). E. P. F. C. is supported by an Australian NHMRC Emerging Leadership Investigator Grant (GNT1172873). M. P. is funded by a NHMRC project grant (APP1144040). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.