Journal article

Imaging Markers of Brain Frailty and Outcome in Patients With Acute Ischemic Stroke

Ning Bu, Mohamed Salah Khlif, Robin Lemmens, Anke Wouters, Jochen B Fiebach, Angel Chamorro, E Bernd Ringelstein, Bo Norrving, Rico Laage, Martin Grond, Guido Wilms, Amy Brodtmann, Vincent Thijs

Stroke | LIPPINCOTT WILLIAMS & WILKINS | Published : 2021

Abstract

BACKGROUND AND PURPOSE: Functional outcome after stroke may be related to preexisting brain health. Several imaging markers of brain frailty have been described including brain atrophy and markers of small vessel disease. We investigated the association of these imaging markers with functional outcome after acute ischemic stroke. METHODS: We retrospectively studied patients with acute ischemic stroke enrolled in the AXIS-2 trial (AX200 in Ischemic Stroke Trial), a randomized controlled clinical trial of granulocyte colony-stimulating factor versus placebo. We assessed the ratio of brain parenchymal volume to total intracerebral volumes (ie, the brain parenchymal fraction) and total brain vol..

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