Journal article

Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement

Shanti Narayanasamy, Roger L Nation, Andrew A Mahony, M Lindsay Grayson, Jason C Kwong, Norelle L Sherry, Sharmila Khumra, Andrew G Ellis, Albert G Frauman, Natasha E Holmes

OPEN FORUM INFECTIOUS DISEASES | OXFORD UNIV PRESS INC | Published : 2021

Abstract

We describe a case of limb-threatening osteomyelitis and metalware infection with carbapenemase-producing extensively drug-resistant Pseudomonas aeruginosa successfully cured with aggressive surgical debridement and combined intravenous fosfomycin and colistin. Real-time therapeutic drug monitoring was used to maximize probability of efficacy and minimize potential for toxicity.