Journal article

Prebiotic and probiotic supplementation and the tryptophan-kynurenine pathway: A systematic review and meta analysis

Terry Purton, Lada Staskova, Melissa M Lane, Samantha L Dawson, Madeline West, Joseph Firth, Gerard Clarke, John F Cryan, Michael Berk, Adrienne O'Neil, Olivia Dean, Amir Hadi, Cynthia Honan, Wolfgang Marx

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2021

Abstract

This systematic review aimed to synthesise the results from studies investigating the effects of prebiotics and probiotics on kynurenine pathway metabolism. Thirteen studies were identified for inclusion, comprising 12 probiotic and two prebiotic arms. Participants included healthy individuals and individuals with various clinical conditions. Twelve metabolites were examined across the studies, using a range of biological samples. Across all interventions, 11 reported an effect on ≤ metabolite. Although limited by clinical and methodological heterogeneity, pooled analysis (n = 253) found probiotics to significantly affect serum kynurenine (g = 0.315, CI = 0.070 to 0.560, p = 0.012, 4 studies..

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University of Melbourne Researchers

Grants

Awarded by University of Manchester Presidential Fellowship


Awarded by UK Research and Innovation Future Leaders Fellowship


Awarded by Science Foundation Ireland (SFI), through the Irish Government's National Development Plan


Awarded by NHMRC Senior Principal Research Fellowship


Awarded by Future Leader Fellowship from the Heart Foundation Australia



Funding Acknowledgements

This research did not receive any specific grant from funding agencies in the public, commercial, or not for profit sectors. TP is supported through an Australian Government Research Training Program Scholarship awarded by the College of Health and Medicine, University of Tasmania. ML is funded by a Deakin University PhD Scholarship. MW is funded by a Deakin University PhD Scholarship. JF is currently supported by a University of Manchester Presidential Fellowship (P123958) and a UK Research and Innovation Future Leaders Fellowship (MR/T021780/1). APC Microbiome Ireland (GC & JFC) is funded by Science Foundation Ireland (SFI), through the Irish Government's National Development Plan (grant number SFI/12/RC/2273 P2). MB is supported by an NHMRC Senior Principal Research Fellowship (1059660 and 1156072). AO is supported by a Future Leader Fellowship (101160) from the Heart Foundation Australia and Wilson Foundation. OMD is a R.D. Wright Biomedical NHMRC Career Development Fellow (APP1145634). WM is currently funded by an Alfred Deakin Postdoctoral Research Fellowship and a Multiple Sclerosis Research Australia early-career fellowship.