Journal article

Male germline development in the tammar wallaby, Macropus eugenii

Teruhito Ishihara, Oliver W Griffith, Gerard A Tarulli, Marilyn B Renfree



Male germ cells undergo two consecutive processes - pre-spermatogenesis and spermatogenesis - to generate mature sperm. In eutherian mammals, epigenetic information such as DNA methylation is dynamically reprogrammed during pre-spermatogenesis, before and during mitotic arrest. In mice, by the time germ cells resume mitosis, the majority of DNA methylation is reprogrammed. The tammar wallaby has a similar pattern of germ cell global DNA methylation reprogramming to that of the mouse during early pre-spermatogenesis. However, early male germline development in the tammar or in any marsupial has not been described previously, so it is unknown whether this is a general feature regulating male g..

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Funding Acknowledgements

This work was supported by the Melbourne Research Scholarship from the University of Melbourne and the Australian Research Council.