Journal article

Obesity defined by body mass index and waist circumference and risk of total knee arthroplasty for osteoarthritis: A prospective cohort study

Yuan Z Lim, Yuanyuan Wang, Flavia M Cicuttini, Graham G Giles, Stephen Graves, Anita E Wluka, Sultana Monira Hussain

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2021

Abstract

OBJECTIVE: To examine the risk of total knee arthroplasty (TKA) due to osteoarthritis associated with obesity defined by body mass index (BMI) or waist circumference (WC) and whether there is discordance between these measures in assessing this risk. METHODS: 36,784 participants from the Melbourne Collaborative Cohort Study with BMI and WC measured at 1990-1994 were included. Obesity was defined by BMI (≥30 kg/m2) or WC (men ≥102cm, women ≥88cm). The incidence of TKA between January 2001 and December 2018 was determined by linking participant records to the National Joint Replacement Registry. RESULTS: Over 15.4±4.8 years, 2,683 participants underwent TKA. There were 20.4% participants with ..

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University of Melbourne Researchers

Grants

Awarded by National Health Medical Research Council (NHMRC)


Awarded by National Health and Medical Research Council (NHMRC) Early Career Fellowship


Awarded by NHMRC Translating Research Into Practice


Funding Acknowledgements

The recruitment of the Melbourne Collaborative Cohort Study was funded by VicHealth and Cancer Council Victoria. This study was funded by a program grants from the National Health Medical Research Council (NHMRC; 209057, 251533, 396414, 623208), and was further supported by infrastructure provided by Cancer Council Victoria. SMH is the recipient of National Health and Medical Research Council (NHMRC) Early Career Fellowship (APP1142198), YW and AEW are the recipients of NHMRC Translating Research Into Practice (APP1168185 and APP1150102, respectively). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.