Journal article

Harnessing liver-resident memory T cells for protection against malaria

Daniel Fernandez-Ruiz, Maria N de Menezes, Lauren E Holz, Sonia Ghilas, William R Heath, Lynette Beattie

Expert Review of Vaccines | TAYLOR & FRANCIS LTD | Published : 2021

Abstract

INTRODUCTION: Tissue-resident memory T cells (TRM cells) are powerful mediators of protracted adaptive immunity to infection in peripheral organs. Harnessing TRM cells through vaccination hence promises unprecedented potential for protection against infection. A paramount example of this is malaria, a major infectious disease for which immunity through traditional vaccination strategies remains challenging. Liver TRM cells appear to be highly protective against malaria, and recent developments in our knowledge of the biology of these cells have defined promising, novel strategies for their induction. AREAS COVERED: Here, we describe the path that led to the discovery of TRM cells and discuss..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by NHMRC


Awarded by Australian Research Council


Funding Acknowledgements

D Fernandez-Ruiz is supported by the National Health and Medical Research Council of Australia (NHMRC 1139486) and the CASS foundation (Medicine/Science grant). WR Heath is supported by NHMRC 1154457, 1113293, and 1124706, and by the Australian Research Council (CE140100011).