Lipid droplets and lipid mediators in viral infection and immunity
Ebony A Monson, Alice M Trenerry, Jay L Laws, Jason M Mackenzie, Karla J Helbig
FEMS MICROBIOLOGY REVIEWS | OXFORD UNIV PRESS | Published : 2021
Lipid droplets (LDs) contribute to key pathways important for the physiology and pathophysiology of cells. In a homeostatic view, LDs regulate the storage of neutral lipids, protein sequestration, removal of toxic lipids and cellular communication; however, recent advancements in the field show these organelles as essential for various cellular stress response mechanisms, including inflammation and immunity, with LDs acting as hubs that integrate metabolic and inflammatory processes. The accumulation of LDs has become a hallmark of infection, and is often thought to be virally driven; however, recent evidence is pointing to a role for the upregulation of LDs in the production of a successful..View full abstract
Awarded by National Health and Medical Research Council of Australia (NHMRC Ideas grant)
This work was funded by the National Health and Medical Research Council of Australia (NHMRC Ideas grant APP1181434) and a La Trobe University Understanding Disease Research Focus Area small grant to KJH. Research performed by JMM was supported by a Melbourne Research Grant Support Scheme grant.