Journal article

A longitudinal analysis of puberty-related cortical development

Nandita Vijayakumar, George Youssef, Nicholas B Allen, Vicki Anderson, Daryl Efron, Philip Hazell, Lisa Mundy, Jan M Nicholson, George Patton, Marc L Seal, Julian G Simmons, Sarah Whittle, Tim Silk

Cold Spring Harbor Laboratory


AbstractThe brain undergoes extensive structural changes during adolescence, concurrent to puberty-related physical and hormonal changes. While animal research suggests these biological processes are related to one another, our knowledge of brain development in humans is largely based on age-related processes. Thus, the current study characterized puberty-related changes in human brain structure, by combining data from two longitudinal neuroimaging cohorts. Beyond normative changes in cortical thickness, we examined whether individual differences in the rate of pubertal maturation (or “pubertal tempo”) was associated with variations in cortical trajectories. Participants (N = 192; scans = 36..

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