Journal article

The novel Dbl homology/BAR domain protein, MsgA, of Talaromyces marneffei regulates yeast morphogenesis during growth inside host cells

Harshini Weerasinghe, Hayley E Bugeja, Alex Andrianopoulos

SCIENTIFIC REPORTS | NATURE RESEARCH | Published : 2021

Abstract

Microbial pathogens have evolved many strategies to evade recognition by the host immune system, including the use of phagocytic cells as a niche within which to proliferate. Dimorphic pathogenic fungi employ an induced morphogenetic transition, switching from multicellular hyphae to unicellular yeast that are more compatible with intracellular growth. A switch to mammalian host body temperature (37 °C) is a key trigger for the dimorphic switch. This study describes a novel gene, msgA, from the dimorphic fungal pathogen Talaromyces marneffei that controls cell morphology in response to host cues rather than temperature. The msgA gene is upregulated during murine macrophage infection, and del..

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Grants

Funding Acknowledgements

We would like to acknowledge the support and feedback of the various lab members who contributed to the ongoing discussion of this project. This work was supported by a National Health and Medical Research Council grant to AA. We also acknowledge the technical support by Jacob Calabria.