Journal article

Relationship between amyloid and tau levels and its impact on tau spreading

Vincent Dore, Natasha Krishnadas, Pierrick Bourgeat, Kun Huang, Shenpeng Li, Samantha Burnham, Colin L Masters, Jurgen Fripp, Victor L Villemagne, Christopher C Rowe

European Journal of Nuclear Medicine and Molecular Imaging | SPRINGER | Published : 2021

Abstract

PURPOSE: Previous studies have shown that Aβ-amyloid (Aβ) likely promotes tau to spread beyond the medial temporal lobe. However, the Aβ levels necessary for tau to spread in the neocortex is still unclear. METHODS: Four hundred sixty-six participants underwent tau imaging with [18F]MK6420 and Aβ imaging with [18F]NAV4694. Aβ scans were quantified on the Centiloid (CL) scale with a cut-off of 25 CL for abnormal levels of Aβ (A+). Tau scans were quantified in three regions of interest (ROI) (mesial temporal (Me); temporoparietal neocortex (Te); and rest of neocortex (R)) and four mesial temporal region (entorhinal cortex, amygdala, hippocampus, and parahippocampus). Regional tau thresholds we..

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