Single-Pulse Transcranial Magnetic Stimulation-Evoked Potential Amplitudes and Latencies in the Motor and Dorsolateral Prefrontal Cortex among Young, Older Healthy Participants, and Schizophrenia Patients
Yoshihiro Noda, Mera S Barr, Reza Zomorrodi, Robin FH Cash, Pantelis Lioumis, Robert Chen, Zafiris J Daskalakis, Daniel M Blumberger
JOURNAL OF PERSONALIZED MEDICINE | MDPI | Published : 2021
BACKGROUND: The combination of transcranial magnetic stimulation (TMS) with electroencephalography (EEG) allows for non-invasive investigation of cortical response and connectivity in human cortex. This study aimed to examine the amplitudes and latencies of each TMS-evoked potential (TEP) component induced by single-pulse TMS (spTMS) to the left motor (M1) and dorsolateral prefrontal cortex (DLPFC) among healthy young participants (YNG), older participants (OLD), and patients with schizophrenia (SCZ). METHODS: We compared the spatiotemporal characteristics of TEPs induced by spTMS among the groups. RESULTS: Compared to YNG, M1-spTMS induced lower amplitudes of N45 and P180 in OLD and a lower..View full abstract
Temerty Centre for Therapeutic Brain Intervention and the Campbell Family Research Institute through the CAMH Foundation, and the Canada Foundation for Innovation.