Journal article
New Technologies to Study Functional Genomics of Age-Related Macular Degeneration
Tu Nguyen, Daniel Urrutia-Cabrera, Roxanne Hsiang-Chi Liou, Chi D Luu, Robyn Guymer, Raymond Ching-Bong Wong
Frontiers in Cell and Developmental Biology | FRONTIERS MEDIA SA | Published : 2021
Abstract
Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss in people over 50 years old in developed countries. Currently, we still lack a comprehensive understanding of the genetic factors contributing to AMD, which is critical to identify effective therapeutic targets to improve treatment outcomes for AMD patients. Here we discuss the latest technologies that can facilitate the identification and functional study of putative genes in AMD pathology. We review improved genomic methods to identify novel AMD genes, advances in single cell transcriptomics to profile gene expression in specific retinal cell types, and summarize recent development of in vitro model..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by funding from the National Health and Medical Research Council (RCBW: GNT1184076; RG) and the Centre for Eye Research Australia (RCBW). TN, DU, and RHCL are supported by the Melbourne Research Scholarship from University of Melbourne. The Centre for Eye Research Australia receives operational infrastructure support from the Victorian Government.