Tuberculosis disease in children and adolescents on therapy with antitumor necrosis factor - A agents: A collaborative, multicenter paediatric tuberculosis network European Trials Group (ptbnet) Study

A Noguera-Julian; J Calzada-Hernández; F Brinkmann; RB Roy; O Bilogortseva; M Buettcher; I Carvalho; V Chechenyeva; L Falcón; F Goetzinger; C Guerrero-Laleona; P Hoffmann; M Jelusic; T Niehues; I Ozere; F Shackley; E Suciliene; SB Welch; EH Schölvinck; N Ritz; M Tebruegge; N Curtis; P Villanueva; B Marais; P Britton; J Clark; J Pichler; A Zschocke; M Bogyi; A Dreesman; F Mouchet; S Velizarova; I Pavic; U Nygaard; A Pulsen; A Kontturi; E Salo; K Chadelat; R Krüger; S Tee; F Ahrens; M Barker; T Zimmermann; U Schulze-Sturm; P Kaiser-Labusch; M Tsolia; OM Ghanaie; D Buonsenso; A Lo Vecchio; I Ivaskeviciene; V Vilc; A Smyrnaios; AS Arbore; A Starshinova; I Solovic; U Krivec; M Aldeco; M Espiau; A Soriano-Arandes; O Neth; B Santiago; D Gómez-Pastrana; D Blázquez; M Bustillo; TM Pérez-Porcuna; MJ Cilleruelo; K Kötz; R Bennet; C Relly; A Niederer-Loher; I Rochat; S Pavskyi; A Riordan; C Doherty; A Bamford; D Shingadia; M Emonts; L Ferreras-Antolín; P McMaster; P Moriarty

Journal article

Tuberculosis disease in children and adolescents on therapy with antitumor necrosis factor - A agents: A collaborative, multicenter paediatric tuberculosis network European Trials Group (ptbnet) Study

A Noguera-Julian, J Calzada-Hernández, F Brinkmann, RB Roy, O Bilogortseva, M Buettcher, I Carvalho, V Chechenyeva, L Falcón, F Goetzinger, C Guerrero-Laleona, P Hoffmann, M Jelusic, T Niehues, I Ozere, F Shackley, E Suciliene, SB Welch, EH Schölvinck, N Ritz Show all

Clinical Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2020

DOI: 10.1093/cid/ciz1138

Abstract

Background. In adults, anti–tumor necrosis factor-α (TNF-α) therapy is associated with progression of latent tuberculosis (TB) infection (LTBI) to TB disease, but pediatric data are limited. Methods. Retrospective multicenter study within the Paediatric Tuberculosis Network European Trials Group, capturing patients <18 years who developed TB disease during anti–TNF-α therapy. Results. Sixty-six tertiary healthcare institutions providing care for children with TB participated. Nineteen cases were identified: Crohn’s disease (n = 8; 42%) and juvenile idiopathic arthritis (n = 6; 32%) were the commonest underlying conditions. Immune-based TB screening (tuberculin skin test and/or interferon-γ r..

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University of Melbourne Researchers

Nigel Curtis Author

Paola Villanueva Author

Grants

Awarded by "Subvencions per a la Intensificacio de Facultatius Especialistes" (Departament de Salut de la Generalitat de Catalunya, Programa Pla Estrategic de Recerca i Innovacio en Salut 2016-2020)

Awarded by MRC

Funding Acknowledgements

This work was supported by "Subvencions per a la Intensificacio de Facultatius Especialistes" (Departament de Salut de la Generalitat de Catalunya, Programa Pla Estrategic de Recerca i Innovacio en Salut 2016-2020) (SLT008/18/00193) (to A. N.-J.), and by Sociedad Espanola de Reumatologia Pediatrica (SERPE) through a grant award "Moving4 ninos con artritis" (to J. C.-H.).