Breast Cancer Risk Factors and Survival by Tumor Subtype: Pooled Analyses from the Breast Cancer Association Consortium
Anna Morra, Audrey Y Jung, Sabine Behrens, Renske Keeman, Thomas U Ahearn, Hoda Anton-Culver, Volker Arndt, Annelie Augustinsson, Paivi K Auvinen, Laura E Beane Freeman, Heiko Becher, Matthias W Beckmann, Carl Blomqvist, Stig E Bojesen, Manjeet K Bolla, Hermann Brenner, Ignacio Briceno, Sara Y Brucker, Nicola J Camp, Daniele Campa Show all
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | AMER ASSOC CANCER RESEARCH | Published : 2021
BACKGROUND: It is not known whether modifiable lifestyle factors that predict survival after invasive breast cancer differ by subtype. METHODS: We analyzed data for 121,435 women diagnosed with breast cancer from 67 studies in the Breast Cancer Association Consortium with 16,890 deaths (8,554 breast cancer specific) over 10 years. Cox regression was used to estimate associations between risk factors and 10-year all-cause mortality and breast cancer-specific mortality overall, by estrogen receptor (ER) status, and by intrinsic-like subtype. RESULTS: There was no evidence of heterogeneous associations between risk factors and mortality by subtype (P adj > 0.30). The strongest associations were..View full abstract
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Awarded by Biomedical Research Council
SGBCC (principal investigators: M. Hartman, J. Li) is funded by the National Research Foundation Singapore, NUS start-up Grant, National University Cancer Institute Singapore (NCIS) Centre Grant, Breast Cancer Prevention Programme, Asian Breast Cancer Research Fund and the NMRC Clinician Scientist Award (SI Category). Additional controls were recruited by the Singapore Consortium of Cohort Studies-Multi-ethnic cohort (SCCS-MEC), which was funded by the Biomedical Research Council, grant number: 05/1/21/19/425.