Journal article

Reciprocal connectivity of the periaqueductal gray with the ponto-medullary respiratory network in rat

Pedro Trevizan-Bau, Werner Furuya, Stuart B Mazzone, Davor Stanic, Rishi R Dhingra, Mathias Dutschmann

BRAIN RESEARCH | ELSEVIER | Published : 2021


Synaptic activities of the periaqueductal gray (PAG) can modulate or appropriate the respiratory motor activities in the context of behavior and emotion via descending projections to nucleus retroambiguus. However, alternative anatomical pathways for the mediation of PAG-evoked respiratory modulation via core nuclei of the brainstem respiratory network remains only partially described. We injected the retrograde tracer Cholera toxin subunit B (CT-B) in the pontine Kölliker-Fuse nucleus (KFn, n = 5), medullary Bötzinger (BötC, n = 3) and pre-Bötzinger complexes (pre-BötC; n = 3), and the caudal raphé nuclei (n = 3), and quantified the descending connectivity of the PAG targeting these brainst..

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University of Melbourne Researchers


Awarded by National Health and Medical Research Council of Australia

Awarded by Australian Research Council

Awarded by Melbourne Research Scholarship (University of Melbourne)

Funding Acknowledgements

This work was supported by research grants from the National Health and Medical Research Council of Australia (APP1165529 to MD & DS, and APP1078943 to SM); and Australian Research Council (Discovery project DP170104861); PT-B is funded by Melbourne Research Scholarship (University of Melbourne; 181858).