Journal article

Acceleration of Enamel Subsurface Lesion Remineralisation by Intralesion pH Modulation

James R Fernando, Peiyan Shen, Glenn D Walker, Yi Yuan, David P Stanton, Coralie Reynolds, Eric C Reynolds

CARIES RESEARCH | KARGER | Published : 2021


Remineralisation of demineralised enamel subsurface lesions can be enhanced by pretreatment of the lesions with base (NaOH). The aim of this study was to test the effect of intralesion pH modulation on remineralisation of demineralised enamel subsurface lesions by casein phosphopeptide-stabilised amorphous calcium fluoride phosphate (CPP-ACFP) in vitro. Two remineralisation models were utilised, the first involving 60-min cyclic pH modulation for 105 h and the second involved short-term cyclic pH modulation (12-min cycle, 240 min total duration) compared with the equivalent time of continuous treatment (200 min total duration). The intralesion pH modulation was achieved by cyclic exposure to..

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Funding Acknowledgements

This study was supported by the Australian Government, Department of Industry, Innovation and Science. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.