Modeling autosomal dominant Alzheimer's disease with machine learning.
Patrick H Luckett, Austin McCullough, Brian A Gordon, Jeremy Strain, Shaney Flores, Aylin Dincer, John McCarthy, Todd Kuffner, Ari Stern, Karin L Meeker, Sarah B Berman, Jasmeer P Chhatwal, Carlos Cruchaga, Anne M Fagan, Martin R Farlow, Nick C Fox, Mathias Jucker, Johannes Levin, Colin L Masters, Hiroshi Mori Show all
Alzheimer's & Dementia | Published : 2021
INTRODUCTION: Machine learning models were used to discover novel disease trajectories for autosomal dominant Alzheimer's disease. METHODS: Longitudinal structural magnetic resonance imaging, amyloid positron emission tomography (PET), and fluorodeoxyglucose PET were acquired in 131 mutation carriers and 74 non-carriers from the Dominantly Inherited Alzheimer Network; the groups were matched for age, education, sex, and apolipoprotein ε4 (APOE ε4). A deep neural network was trained to predict disease progression for each modality. Relief algorithms identified the strongest predictors of mutation status. RESULTS: The Relief algorithm identified the caudate, cingulate, and precuneus as the str..View full abstract