Journal article

miRNAs in Microglia: Important Players in Multiple Sclerosis Pathology

Alexander D Walsh, Linda T Nguyen, Michele D Binder



Microglia are the resident immune cells of the central nervous system and important regulators of brain homeostasis. Central to this role is a dynamic phenotypic plasticity that enables microglia to respond to environmental and pathological stimuli. Importantly, different microglial phenotypes can be both beneficial and detrimental to central nervous system health. Chronically activated inflammatory microglia are a hallmark of neurodegeneration, including the autoimmune disease multiple sclerosis (MS). By contrast, microglial phagocytosis of myelin debris is essential for resolving inflammation and promoting remyelination. As such, microglia are being explored as a potential therapeutic targ..

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University of Melbourne Researchers


Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work is supported by the Australian Government Research Training Programme Scholarship to (A. D. W.), Florey Institute Alan and Elizabeth Finkel Award (to A. W.), and John A McKenzie/Selby Scientific Foundation Award (to A. D. W.). The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.