Journal article

Subthreshold Nano-Second Laser Treatment and Age-Related Macular Degeneration

Amy C Cohn, Zhichao Wu, Andrew I Jobling, Erica L Fletcher, Robyn H Guymer



The presence of drusen is an important hallmark of age-related macular degeneration (AMD). Laser-induced regression of drusen, first observed over four decades ago, has led to much interest in the potential role of lasers in slowing the progression of the disease. In this article, we summarise the key insights from pre-clinical studies into the possible mechanisms of action of various laser interventions that result in beneficial changes in the retinal pigment epithelium/Bruch's membrane/choriocapillaris interface. Key learnings from clinical trials of laser treatment in AMD are also summarised, concentrating on the evolution of laser technology towards short pulse, non-thermal delivery such..

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Awarded by National Health & Medical Research Council of Australia

Funding Acknowledgements

This study was supported by the National Health & Medical Research Council of Australia (project grant no.: APP1027624 [RHG and CDL], and fellowship grant no.: GNT1103013 (RHG), APP1104985 [ZW], APP1054712 [FKC], APP1142962 [FKC] and GNT1128343 [SSW]), and the BUPA Health Foundation (Australia) (RHG and CDL). The Centre for Eye Research Australia (CERA) receives operational infrastructure support from the Victorian Government. Ellex R&D Pty Ltd. (Adelaide, Australia) provided partial funding of the central coordinating centre and the in-kind provision of Ellex 2RTTM laser systems, ongoing support of those systems, and the Macular Integrity Assessment micro-perimeters for the duration of the study. The web-based Research Electronic Data Capture (REDCap) application and open-source platform OpenClinica allowed secure electronic data capture. The study is sponsored by CERA, an independent medical research institute and a not-for-profit company.