A comparative analysis of sepsis digital phenotyping methods

Abstract

Health data captured in Electronic health records (EHRs) have enabled the development of computational approaches to improve patient management and treatment, including early diagnosis of severe conditions such as sepsis. The validity of these efforts, however, largely relies on which sepsis definition is used and the quality of the underlying data. Here we tested different sepsis definitions to better understand how phenotyping approaches may impact the classification accuracy of sepsis prediction algorithms. To assess the extent to which sepsis definitions (dis)agree with each other, we have analised a large cohort of patients admitted to the ICU (over 22,000) from MIMIC-IV. Cases were c..