Second primary cancers in patients with sporadic deficient mismatch repair (dMMR) colorectal cancer (CRC).
Ayman Alidina, Lara Rachel Lipton, Lucy Gately, Iain Skinner, Shehara Ramyalini Mendis, Wei Hong, Catherine Dunn, Jin Cho, Yat Hang To, Malcolm Steel, Ian Jones, Margaret Lee, Jeanne Tie, Suzanne Kosmider, Rachel Wong, Justin Yeung, Peter Gibbs
JOURNAL OF CLINICAL ONCOLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2021
45 Background: Patients with hereditary non polyposis colorectal cancer (HNPCC) diagnosed with CRC have an elevated risk of a second primary CRC (SPCRC) and of rapid primary cancer development. This informs both initial surgical approach and endoscopic surveillance intervals. A feature of HNPCC is dMMR, also found in 15% of sporadic CRC, where the risk of SPCRC has yet to be defined. Methods: We examined a multi-site comprehensive CRC database (Melbourne, Australia), where prospectively collected data includes family history (including HNPCC), histology, surgery performed and incidence of second primary cancer. Sporadic dMMR included any case with a BRAF V600E mutation, confirmed hypermethy..View full abstract