Considerations for the Bioengineering of Advanced Cardiac In Vitro Models of Myocardial Infarction
Poonam Sharma, Xiaowei Wang, Clara Liu Chung Ming, Laura Vettori, Gemma Figtree, Andrew Boyle, Carmine Gentile
SMALL | WILEY-V C H VERLAG GMBH | Published : 2021
Despite the latest advances in cardiovascular biology and medicine, myocardial infarction (MI) remains one of the major causes of deaths worldwide. While reperfusion of the myocardium is critical to limit the ischemic damage typical of a MI event, it causes detrimental morphological and functional changes known as "reperfusion injury." This complex scenario is poorly represented in currently available models of ischemia/reperfusion injury, leading to a poor translation of findings from the bench to the bedside. However, more recent bioengineered in vitro models of the human heart represent more clinically relevant tools to prevent and treat MI in patients. These include 3D cultures of cardia..View full abstract
Awarded by UNRS Central & Faculty School (University of Newcastle, Australia)
P.S. was supported by the UNIPRS and UNRS Central & Faculty School (Grant No. UNRSC5050) (University of Newcastle, Australia). C.G. was supported by a University of Sydney Kick-Start Grant, CDIP Grant, Cardiothoracic Surgery Research Grant, UTS Seed Funding, and Catholic Archdiocese of Sydney Grant for Adult Stem Cell Research.