Intracellular Staphylococcus aureus and host cell death pathways
Ye Mon Soe, Sammy Bedoui, Timothy P Stinear, Abderrahman Hachani
CELLULAR MICROBIOLOGY | WILEY | Published : 2021
Staphylococcus aureus is a major opportunistic human pathogen that is globally prevalent. Although S. aureus and humans may have co-evolved to the point of commensalism, the bacterium is equipped with virulence factors causing devastating infections. The adoption of an intracellular lifestyle by S. aureus is an important facet of its pathogenesis. Occupying a privileged intracellular compartment permits evasion from the bactericidal actions of host immunity and antibiotics. However, this localization exposes S. aureus to cell-intrinsic processes comprising autophagy, metabolic challenges and clearance mechanisms orchestrated by host programmed cell death pathways (PCDs), including apoptosis,..View full abstract
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Awarded by National Health and Medical Research Council
Awarded by Australian Research Council
We apologise to all colleagues whose work has not been mentioned in this manuscript due to space limitations. We are grateful to Dr Hayley Newton and Dr Charlotte Odendall for critically reading the manuscript. Figures created with BioRender.com. The funding number are TGNT1059937, GNT1105525, and GNT1159658. Timothy Stinear (TS) is supported by a fellowship from the National Health and Medical Research Council (NHMRC-APP1105525). Abderrahman Hachani (AH) and TS are supported by a National Health and Medical Research Council grant (NHMRC-APP1145631). Sammy Bedoui (SB) is supported by the National Health and Medical Research Council grants (NHMRC-APP1159658 & 1059937) and the Australian Research Council grant (ARC-DP210101806).