Journal article
Personalized connectivity-guided DLPFC-TMS for depression: Advancing computational feasibility, precision and reproducibility
Robin FH Cash, Luca Cocchi, Jinglei Lv, Yumeng Wu, Paul B Fitzgerald, Andrew Zalesky
Human Brain Mapping | WILEY | Published : 2021
DOI: 10.1002/hbm.25330
Abstract
Repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex (DLPFC) is an established treatment for refractory depression, however, therapeutic outcomes vary. Mounting evidence suggests that clinical response relates to functional connectivity with the subgenual cingulate cortex (SGC) at the precise DLPFC stimulation site. Critically, SGC-related network architecture shows considerable interindividual variation across the spatial extent of the DLPFC, indicating that connectivity-based target personalization could potentially be necessary to improve treatment outcomes. However, to date accurate personalization has not appeared feasible, with recent work indicatin..
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Grants
Awarded by Australian Research Council
Awarded by Australian National Health and Medical Research Council (NHMRC)
Funding Acknowledgements
Australian Research Council, Grant/Award Number: DE200101708; Australian National Health and Medical Research Council (NHMRC), Grant/Award Numbers: APP1099082, APP1138711, 1136649