Journal article

Personalized connectivity-guided DLPFC-TMS for depression: Advancing computational feasibility, precision and reproducibility

Robin FH Cash, Luca Cocchi, Jinglei Lv, Yumeng Wu, Paul B Fitzgerald, Andrew Zalesky

HUMAN BRAIN MAPPING | WILEY | Published : 2021

Abstract

Repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex (DLPFC) is an established treatment for refractory depression, however, therapeutic outcomes vary. Mounting evidence suggests that clinical response relates to functional connectivity with the subgenual cingulate cortex (SGC) at the precise DLPFC stimulation site. Critically, SGC-related network architecture shows considerable interindividual variation across the spatial extent of the DLPFC, indicating that connectivity-based target personalization could potentially be necessary to improve treatment outcomes. However, to date accurate personalization has not appeared feasible, with recent work indicatin..

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Grants

Awarded by Australian Research Council


Awarded by Australian National Health and Medical Research Council (NHMRC)


Funding Acknowledgements

Australian Research Council, Grant/Award Number: DE200101708; Australian National Health and Medical Research Council (NHMRC), Grant/Award Numbers: APP1099082, APP1138711, 1136649