Effects of Standard vs Energy-Dense Formulae on Gastric Retention, Energy Delivery, and Glycemia in Critically Ill Patients
Lee-anne S Chapple, Matthew J Summers, Luke M Weinel, Yasmine Ali Abdelhamid, Palash Kar, Seva Hatzinikolas, Deborah Calnan, Madison Bills, Kylie Lange, Alexis Poole, Stephanie N O'Connor, Michael Horowitz, Karen L Jones, Adam M Deane, Marianne J Chapman
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION | WILEY | Published : 2021
BACKGROUND: Energy-dense formulae are often provided to critically ill patients with enteral feed intolerance with the aim of increasing energy delivery, yet the effect on gastric emptying is unknown. The rate of gastric emptying of a standard compared with an energy-dense formula was quantified in critically ill patients. METHODS: Mechanically ventilated adults were randomized to receive radiolabeled intragastric infusions of 200 mL standard (1 kcal/mL) or 100 mL energy-dense (2 kcal/mL) enteral formulae on consecutive days in this noninferiority, blinded, crossover trial. The primary outcome was scintigraphic measurement of gastric retention (percentage at 120 minutes). Other measures incl..View full abstract
This study was supported by an American Society of Parenteral and Enteral Nutrition Research Grant. The Royal Adelaide Hospital provided infrastructure and administrative support.