Incidence and management of metabolic acidosis with sodium bicarbonate in the ICU: An international observational study
Tomoko Fujii, Andrew A Udy, Alistair Nichol, Rinaldo Bellomo, Adam M Deane, Khaled El-Khawas, Naorungroj Thummaporn, Ary Serpa Neto, Hannah Bergin, Robert Short-Burchell, Chin-Ming Chen, Kuang-Hua Cheng, Kuo-Chen Cheng, Clemente Chia, Feng-Fan Chiang, Nai-Kuan Chou, Timothy Fazio, Pin-Kuei Fu, Victor Ge, Yoshiro Hayashi Show all
CRITICAL CARE | BMC | Published : 2021
BACKGROUND: Metabolic acidosis is a major complication of critical illness. However, its current epidemiology and its treatment with sodium bicarbonate given to correct metabolic acidosis in the ICU are poorly understood. METHOD: This was an international retrospective observational study in 18 ICUs in Australia, Japan, and Taiwan. Adult patients were consecutively screened, and those with early metabolic acidosis (pH < 7.3 and a Base Excess < -4 mEq/L, within 24-h of ICU admission) were included. Screening continued until 10 patients who received and 10 patients who did not receive sodium bicarbonate in the first 24 h (early bicarbonate therapy) were included at each site. The primary outco..View full abstract
This study was supported by Jikei University Research Grant to TF. The funding body did not take any role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.