Journal article

Neuroprotective Properties of Vitamin C: A Scoping Review of Pre-Clinical and Clinical Studies

Lauren Kangisser, Elinor Tan, Rinaldo Bellomo, Adam M Deane, Mark P Plummer

Journal of Neurotrauma | MARY ANN LIEBERT, INC | Published : 2021


There is a need for novel neuroprotective therapies. We aimed to review the evidence for exogenous vitamin C as a neuroprotective agent. MEDLINE, Embase, and Cochrane library databases were searched from inception to May 2020. Pre-clinical and clinical reports evaluating vitamin C for acute neurological injury were included. Twenty-two pre-clinical and 11 clinical studies were eligible for inclusion. Pre-clinical studies included models of traumatic and hypoxic brain injury, subarachnoid and intracerebral hemorrhage, and ischemic stroke. The median [IQR] maximum daily dose of vitamin C in animal studies was 120 [50-500] mg/kg. Twenty-one animal studies reported improvements in biomarkers, fu..

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