Chronic lung diseases: prospects for regeneration and repair
Peter J Barnes, Gary P Anderson, Malin Fageras, Maria G Belvisi
EUROPEAN RESPIRATORY REVIEW | EUROPEAN RESPIRATORY SOC JOURNALS LTD | Published : 2021
COPD and idiopathic pulmonary fibrosis (IPF) together represent a considerable unmet medical need, and advances in their treatment lag well behind those of other chronic conditions. Both diseases involve maladaptive repair mechanisms leading to progressive and irreversible damage. However, our understanding of the complex underlying disease mechanisms is incomplete; with current diagnostic approaches, COPD and IPF are often discovered at an advanced stage and existing definitions of COPD and IPF can be misleading. To halt or reverse disease progression and achieve lung regeneration, there is a need for earlier identification and treatment of these diseases. A precision medicine approach to t..View full abstract
The development of this article was funded by AstraZeneca, Cambridge, UK.