Journal article

Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma

James R Tribble, Flora Hui, Melissa Joe, Katharina Bell, Vicki Chrysostomou, Jonathan G Crowston, Pete A Williams

CELLS | MDPI | Published : 2021

Abstract

Glaucoma is a leading cause of blindness worldwide. In glaucoma, a progressive dysfunction and death of retinal ganglion cells occurs, eliminating transfer of visual information to the brain. Currently, the only available therapies target the lowering of intraocular pressure, but many patients continue to lose vision. Emerging pre-clinical and clinical evidence suggests that metabolic deficiencies and defects may play an important role in glaucoma pathophysiology. While pre-clinical studies in animal models have begun to mechanistically uncover these metabolic changes, some existing clinical evidence already points to potential benefits in maintaining metabolic fitness. Modifying diet and ex..

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Grants

Awarded by Vetenskapsradet


Funding Acknowledgements

Vetenskapsradet 2018-02124 (PAW). Pete Williams is supported by Karolinska Institutet in the form of a Board of Research faculty-funded career position, and by philanthropic donations from St. Erik Eye Hospital.