Journal article

Novel virus-like particle vaccine encoding the circumsporozoite protein of Plasmodium falciparum is immunogenic and induces functional antibody responses

Liriye Kurtovic, David Wetzel, Linda Reiling, Damien Drew, Catherine Palmer, Betty Kouskousis, Eric Hanssen, Bruce Wines, Mark Hogarth, Manfred Suckow, Volker Jenzelewski, Michael Piontek, Jo-Anne Chan, James Beeson

Published : 2020

Abstract

RTS,S is the leading malaria vaccine in development, but has demonstrated only moderate protective efficacy in clinical trials. RTS,S is a virus-like particle (VLP) that uses the human hepatitis B virus as scaffold to display the malaria sporozoite antigen, circumsporozoite protein (CSP). Particle formation requires fourfold excess scaffold antigen, and as a result, CSP represents only a small portion of the final vaccine construct. Alternative VLP or nanoparticle platforms that reduce the amount of scaffold antigen and increase the amount of the target CSP antigen present in particles may enhance vaccine immunogenicity and efficacy. Here, we describe the production and characterization of a..

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