Parasite-Host Dynamics throughout Antimalarial Drug Development Stages Complicate the Translation of Parasite Clearance
Lydia Burgert, Sophie Zaloumis, Saber Dini, Louise Marquart, Pengxing Cao, Mohammed Cherkaoui, Nathalie Gobeau, James McCarthy, Julie A Simpson, Jorg J Mohrle, Melissa A Penny
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | AMER SOC MICROBIOLOGY | Published : 2021
Ensuring continued success against malaria depends on a pipeline of new antimalarials. Antimalarial drug development utilizes preclinical murine and experimental human malaria infection studies to evaluate drug efficacy. A sequential approach is typically adapted, with results from each stage informing the design of the next stage of development. The validity of this approach depends on confidence that results from murine malarial studies predict the outcome of clinical trials in humans. Parasite clearance rates following treatment are key parameters of drug efficacy. To investigate the validity of forward predictions, we developed a suite of mathematical models to capture parasite growth an..View full abstract
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Awarded by Swiss National Science Foundation
Awarded by Australian National Health and Medical Research Council
The work was funded by the Swiss National Science Foundation through SNSF Professorship of MAP (PP00P3_170702). Calculations were performed at sciCORE (http://scicore.unibas.ch/) scientific computing center at University of Basel. J. A. Simpson is supported by an Australian National Health and Medical Research Council Senior Research Fellowship (1104975).