Journal article

Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer's disease.

James M Roe, Didac Vidal-Piñeiro, Øystein Sørensen, Andreas M Brandmaier, Sandra Düzel, Hector A Gonzalez, Rogier A Kievit, Ethan Knights, Simone Kühn, Ulman Lindenberger, Athanasia M Mowinckel, Lars Nyberg, Denise C Park, Sara Pudas, Melissa M Rundle, Kristine B Walhovd, Anders M Fjell, René Westerhausen, undefined Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing

Nature Communications | Published : 2021


Aging and Alzheimer's disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an organizing feature of the cerebral cortex it is unknown whether continuous age- and AD-related cortical degradation alters cortical asymmetry. Here, in multiple longitudinal adult lifespan cohorts we show that higher-order cortical regions exhibiting pronounced asymmetry at age ~20 also show progressive asymmetry-loss across the adult lifespan. Hence, accelerated thinning of the (previously) thicker homotopic hemisphere is a feature of aging. This organizational principle showed high consistency across cohorts in the Lifebrain consortium, and both the topological patt..

View full abstract