Journal article

Prenatal valproate exposure and adverse neurodevelopmental outcomes: Does sex matter?

Eliza Honybun, Rebecca Thwaites, Charles B Malpas, Genevieve Rayner, Alison Anderson, Janet Graham, Alison Hitchcock, Terence J O'Brien, Frank JE Vajda, Piero Perucca

Epilepsia | WILEY | Published : 2021

Abstract

OBJECTIVE: Prenatal exposure to the antiepileptic drug (AED) valproic acid (VPA) is associated with an increased risk of impaired postnatal neurodevelopment, including autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). We aimed to evaluate the influence of sex and drug dosage on the association between prenatal VPA exposure and postnatal behavioral outcomes. METHODS: The Australian Pregnancy Register of AEDs was interrogated to identify children aged 4-11 years prenatally exposed to AEDs. Parents reported on their child's behavior using the Autism Spectrum Quotient-Children's Version and the National Institute for Children's Health Quality Vanderbilt Assessme..

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Grants

Funding Acknowledgements

Epilepsy Action Australia; Epilepsy Society of Australia; the Royal Melbourne Hospital Neuroscience Foundation; Sanofi-Aventis; Genzyme; UCB Pharma; Janssen-Cilag; Sci-Gen; Eisai