Journal article

What Is the "Optimal" Target Mismatch Criteria for Acute Ischemic Stroke?

Chushuang Chen, Mark W Parsons, Christopher R Levi, Neil J Spratt, Longting Lin, Timothy Kleinig, Kenneth Butcher, Xin Cheng, Qiang Dong, Billy O'Brien, Richard I Avivi, Martin Krause, PN Sylaja, Philip Choi, Sandeep Bhuta, Congguo Yin, Jianhong Yang, Peng Wang, Weiwen Qiu, Andrew Bivard

FRONTIERS IN NEUROLOGY | FRONTIERS MEDIA SA | Published : 2021

Abstract

We aimed to compare Perfusion Imaging Mismatch (PIM) and Clinical Core Mismatch (CCM) criteria in ischemic stroke patients to identify the effect of these criteria on selected patient population characteristics and clinical outcomes. Patients from the INternational Stroke Perfusion Imaging REgistry (INSPIRE) who received reperfusion therapy, had pre-treatment multimodal CT, 24-h imaging, and 3 month outcomes were analyzed. Patients were divided into 3 cohorts: endovascular thrombectomy (EVT), intravenous thrombolysis alone with large vessel occlusion (IVT-LVO), and intravenous thrombolysis alone without LVO (IVT-nonLVO). Patients were classified using 6 separate mismatch criteria: PIM-using ..

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Grants

Awarded by NHMRC/NHF


Awarded by National Key R&D Program of China


Funding Acknowledgements

NS was the recipient of a co-funded NHMRC/NHF Career Development/Future Leader Fellowship APP1110629/ 100827. XC and QD were supported by National Key R&D Program of China 2017YFC1308201.