Intervention strategies for ultra-high risk for psychosis: Progress in delaying the onset and reducing the impact of first-episode psychosis
Patrick D McGorry, Cristina Mei, Jessica Hartmann, Alison R Yung, Barnaby Nelson
Schizophrenia Research | ELSEVIER | Published : 2021
Over a quarter of a century ago, the formulation of the "at risk mental state" and operational criteria to prospectively identify individuals at "clinical" or "ultra-high risk" (UHR) for psychosis created a global wave of research momentum aimed at predicting and preventing first-episode psychosis. A substantial number of randomized controlled trials (RCTs) were conducted to determine if transition to psychosis could be delayed or even prevented. The efficacy of a range of interventions was examined, with standard meta-analyses clearly indicating that these could at least delay transition for 1-2 years and that outcomes improve. Recently, network meta-analyses have attempted to identify the ..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC)
PDM is supported by a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship (1155508). BN is supported by a NHMRC Senior Research Fellowship (1137687). JH is supported by a University of Melbourne McKenzie Fellowship. ARY is supported by a NHMRC Principal Research Fellowship (1136829).