Journal article

TLR2-mediated activation of innate responses in the upper airways confers antiviral protection of the lungs

Georgia Deliyannis, Chinn Yi Wong, Hayley A McQuilten, Annabell Bachem, Michele Clarke, Xiaoxiao Jia, Kylie Horrocks, Weiguang Zeng, Jason Girkin, Nichollas E Scott, Sarah L Londrigan, Patrick C Reading, Nathan W Bartlett, Katherine Kedzierska, Lorena E Brown, Francesca Mercuri, Christophe Demaison, David C Jackson, Brendon Y Chua

JCI INSIGHT | AMER SOC CLINICAL INVESTIGATION INC | Published : 2021

Abstract

The impact of respiratory virus infections on global health is felt not just during a pandemic, but endemic seasonal infections pose an equal and ongoing risk of severe disease. Moreover, vaccines and antiviral drugs are not always effective or available for many respiratory viruses. We investigated how induction of effective and appropriate antigen-independent innate immunity in the upper airways can prevent the spread of respiratory virus infection to the vulnerable lower airways. Activation of TLR2, when restricted to the nasal turbinates, resulted in prompt induction of innate immune-driven antiviral responses through action of cytokines, chemokines, and cellular activity in the upper bu..

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by NHMRC


Funding Acknowledgements

This work was supported by a program grant from the National Health and Medical Research Council of Australia (NHMRC; 1071916) and a partnership between the University of Melbourne and Ena Respiratory. BYC is supported by a CR Roper Fellowship from the University of Melbourne. XJ is supported by China Scholarship Council-University of Melbourne joint scholarship. KK is supported by an NHMRC Senior Research Fellowship Level B (1102792), Investigator Grant (1173871), and University of Melbourne Dame Kate Campbell Fellowship. The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health.