Journal article

Methylation scores for smoking, alcohol consumption, and body mass index and risk of seven types of cancer

Pierre-Antoine Dugué, Chenglong Yu, Allison Hodge, Ee Ming Wong, JiHoon Joo, Chol-Hee Jung, Daniel Schmidt, Enes Makalic, Daniel Buchanan, Gianluca Severi, Dallas English, John Hopper, Roger Milne, Graham Giles, Melissa Southey

Cold Spring Harbor Laboratory | Published : 2021


ABSTRACT Methylation marks of exposure to health risk factors may be useful markers of cancer risk as they might better capture current and past exposures than questionnaires, and reflect different individual responses to exposure. We used data from seven case-control studies nested within the Melbourne Collaborative Cohort Study of blood DNA methylation and risk of colorectal, gastric, kidney, lung, prostate and urothelial cancer, and B-cell lymphoma (N cases=3,123). Methylation scores (MS) for smoking, body mass index (BMI), and alcohol consumption were calculated based on published data as weighted averages of methylation values. Rate ratios (RR) and 95% confidence intervals for associati..

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