Journal article

Familial and Genetic Influences on the Common Pediatric Primary Pain Disorders: A Twin Family Study

David Champion, Minh Bui, Aneeka Bott, Theresa Donnelly, Shuxiang Goh, Cindy Chapman, Daniel Lemberg, Tiina Jaaniste, John Hopper

CHILDREN-BASEL | MDPI | Published : 2021


The primary pain disorders of childhood are highly prevalent but have infrequently been studied collectively. Genetic influences have been suggested to be causally implicated. Surveys were sent to 3909 Australian twin families, assessing the lifetime prevalence of growing pains, migraine, headache, recurrent abdominal pain, low back pain, and persistent pain (not otherwise specified) in pediatric twins and their immediate family members. Comparisons between monozygous (MZ) and dizygous (DZ) twin pair correlations, concordances and odds ratios were performed to assess the contribution of additive genetic influences. Random-effects logistic regression modelling was used to evaluate relationshi..

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Funding Acknowledgements

This research was funded by the School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Australia, and by private donors.