Journal article

Valproic acid influences the expression of genes implicated with hyperglycaemia-induced complement and coagulation pathways.

Marina Barreto Felisbino, Mark Ziemann, Ishant Khurana, Jun Okabe, Keith Al-Hasani, Scott Maxwell, KN Harikrishnan, Camila Borges Martins de Oliveira, Maria Luiza S Mello, Assam El-Osta

Scientific Reports | Published : 2021

Abstract

Because the liver plays a major role in metabolic homeostasis and secretion of clotting factors and inflammatory innate immune proteins, there is interest in understanding the mechanisms of hepatic cell activation under hyperglycaemia and whether this can be attenuated pharmacologically. We have previously shown that hyperglycaemia stimulates major changes in chromatin organization and metabolism in hepatocytes, and that the histone deacetylase inhibitor valproic acid (VPA) is able to reverse some of these metabolic changes. In this study, we have used RNA-sequencing (RNA-seq) to investigate how VPA influences gene expression in hepatocytes. Interesting, we observed that VPA attenuates hyper..

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University of Melbourne Researchers

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Awarded by Fundação de Amparo à Pesquisa do Estado de São Paulo


Awarded by Conselho Nacional de Desenvolvimento Científico e Tecnológico


Awarded by National Health and Medical Research Council


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