Journal article

Can semiology differentiate between bilateral tonic-clonic seizures of focal-onset and generalized-onset? A systematic review

Harry Christie, Wendyl D'Souza, Mark Cook, Udaya Seneviratne

Epilepsy & Behavior | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2021


OBJECTIVE: Bilateral tonic-clonic seizures are encountered in both focal and generalized epilepsies. We reviewed the literature regarding the presence of focal signs in generalized-onset tonic-clonic seizures (GOTCS) and the utility of semiology in differentiating those from focal to bilateral tonic-clonic seizures (FBTCS). METHODS: We conducted a comprehensive literature search using four electronic databases (Medline, Embase, Web of Science, and Psychinfo) and constructed a systematic review in keeping with the Preferred Items for Systematic Reviews and Meta-analyses guidelines. RESULTS: We included 13 studies on focal semiological features of GOTCS. These studies included a total of 952 p..

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