Type 2 Innate Lymphoid Cells Protect against Colorectal Cancer Progression and Predict Improved Patient Survival
Qiutong Huang, Nicolas Jacquelot, Adele Preaudet, Soroor Hediyeh-zadeh, Fernando Souza-Fonseca-Guimaraes, Andrew NJ McKenzie, Philip M Hansbro, Melissa J Davis, Lisa A Mielke, Tracy L Putoczki, Gabrielle T Belz
CANCERS | MDPI | Published : 2021
Chronic inflammation of the gastrointestinal (GI) tract contributes to colorectal cancer (CRC) progression. While the role of adaptive T cells in CRC is now well established, the role of innate immune cells, specifically innate lymphoid cells (ILCs), is not well understood. To define the role of ILCs in CRC we employed complementary heterotopic and chemically-induced CRC mouse models. We discovered that ILCs were abundant in CRC tumours and contributed to anti-tumour immunity. We focused on ILC2 and showed that ILC2-deficient mice developed a higher tumour burden compared with littermate wild-type controls. We generated an ILC2 gene signature and using machine learning models revealed that C..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
Awarded by Cancer Australia through the Cancer Australia Priority-driven Cancer Research Scheme
This work was funded by grants and fellowships from the National Health and Medical Research Council (NHMRC) of Australia (APP1165443, 1122277, 1054925, 1135898, 1123000 to G.T.B., 1047903 to G.T.B. and L.A.M., 1147621 to T.L.P., and 1175134 to P.M.H.), a grant to The University of Queensland Chair of Immunology (Diamantina Institute, G.T.B.), Cure Cancer Australia and Cancer Australia through the Cancer Australia Priority-driven Cancer Research Scheme (APP1163990, N.J. and 1050241, L.A.M.), a fellowship from the Foundation ARC pour la recherche sur le cancer (N.J.), the Sylvia and Charles Viertel Charitable Foundation (Senior Medical Research Fellowship, T.L.P.), Victorian Cancer Agency Mid-Career Fellowship (L.A.M.; T.L.P.). This work was supported through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIIS.