Journal article

Ferroptosis: mechanisms and links with diseases

Hong-fa Yan, Ting Zou, Qing-zhang Tuo, Shuo Xu, Hua Li, Abdel Ali Belaidi, Peng Lei

SIGNAL TRANSDUCTION AND TARGETED THERAPY | SPRINGERNATURE | Published : 2021

Abstract

Ferroptosis is an iron-dependent cell death, which is different from apoptosis, necrosis, autophagy, and other forms of cell death. The process of ferroptotic cell death is defined by the accumulation of lethal lipid species derived from the peroxidation of lipids, which can be prevented by iron chelators (e.g., deferiprone, deferoxamine) and small lipophilic antioxidants (e.g., ferrostatin, liproxstatin). This review summarizes current knowledge about the regulatory mechanism of ferroptosis and its association with several pathways, including iron, lipid, and cysteine metabolism. We have further discussed the contribution of ferroptosis to the pathogenesis of several diseases such as cancer..

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Grants

Awarded by Ministry of Science and Technology of China


Awarded by National Natural Science Foundation of China


Awarded by Alzheimer's Association


Funding Acknowledgements

Supported by funds from the Ministry of Science and Technology of China (2018YFC1312300), The National Natural Science Foundation of China (81722016, 82071191), The Alzheimer's Association (AARFD-16-442821).