Journal article

B-cells expressing NgR1 and NgR3 are localized to EAE-induced inflammatory infiltrates and are stimulated by BAFF

Maha M Bakhuraysah, Paschalis Theotokis, Jae Young Lee, Amani A Alrehaili, Pei-Mun Aui, William A Figgett, Michael F Azari, John-Paul Abou-Afech, Fabienne Mackay, Christopher Siatskas, Frank Alderuccio, Stephen M Strittmatter, Nikolaos Grigoriadis, Steven Petratos

SCIENTIFIC REPORTS | NATURE RESEARCH | Published : 2021

Abstract

We have previously reported evidence that Nogo-A activation of Nogo-receptor 1 (NgR1) can drive axonal dystrophy during the neurological progression of experimental autoimmune encephalomyelitis (EAE). However, the B-cell activating factor (BAFF/BlyS) may also be an important ligand of NgR during neuroinflammation. In the current study we define that NgR1 and its homologs may contribute to immune cell signaling during EAE. Meningeal B-cells expressing NgR1 and NgR3 were identified within the lumbosacral spinal cords of ngr1+/+ EAE-induced mice at clinical score 1. Furthermore, increased secretion of immunoglobulins that bound to central nervous system myelin were shown to be generated from is..

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University of Melbourne Researchers

Grants

Awarded by Multiple Sclerosis Research Australia


Awarded by National Multiple Sclerosis Society


Awarded by International Progressive Multiple Sclerosis Alliance Challenge Award


Awarded by Trish Multiple Sclerosis Research Foundation


Awarded by Bethlehem Griffiths Research Foundation


Funding Acknowledgements

JYL supported by Multiple Sclerosis Research Australia and Trish Multiple Sclerosis Research Foundation Postgraduate Scholarship; SP supported by National Multiple Sclerosis Society Project Grant #RG4398A1/1, International Progressive Multiple Sclerosis Alliance Challenge Award #PA0065, Multiple Sclerosis Research Australia and Trish Multiple Sclerosis Research Foundation #15-022 and Bethlehem Griffiths Research Foundation #BGRF1706. S.M.S supported by N.I.H. The authors thank Stephen Cody from Monash Micro Imaging, Central Clinical School, Monash University, Melbourne, Australia.