Journal article

Investigating the microstructural properties of normal-appearing white matter (NAWM) preceding conversion to white matter hyperintensities (WMHs) in stroke survivors

Wasim Khan, Mohamed Salah Khlif, Remika Mito, Thijs Dhollander, Amy Brodtmann

NeuroImage | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2021

Abstract

Using advanced diffusion MRI, we aimed to assess the microstructural properties of normal-appearing white matter (NAWM) preceding conversion to white matter hyperintensities (WMHs) using 3-tissue diffusion signal compositions in ischemic stroke. Data were obtained from the Cognition and Neocortical Volume After Stroke (CANVAS) study. Diffusion-weighted MR and high-resolution structural brain images were acquired 3- (baseline) and 12-months (follow-up) post-stroke. WMHs were automatically segmented and longitudinal assessment at 12-months was used to retrospectively delineate NAWM voxels at baseline converting to WMHs. NAWM voxels converting to WMHs were further dichotomized into either: "gro..

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University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council (NHMRC) Dementia Research Team Grant at the Florey Institute of Neuroscience and Mental Health, Melbourne, Australia


Funding Acknowledgements

This work is supported by the National Health and Medical Research Council (NHMRC) Dementia Research Team Grant (APP1094974) at the Florey Institute of Neuroscience and Mental Health, Melbourne, Australia.