Transfer of rhodamine-123 into the brain and cerebrospinal fluid of fetal, neonatal and adult rats
Liam M Koehn, Katarzyna M Dziegielewska, Mark D Habgood, Yifan Huang, Norman R Saunders
Fluids and Barriers of the CNS | BMC | Published : 2021
BACKGROUND: Adenosine triphosphate binding cassette transporters such as P-glycoprotein (PGP) play an important role in drug pharmacokinetics by actively effluxing their substrates at barrier interfaces, including the blood-brain, blood-cerebrospinal fluid (CSF) and placental barriers. For a molecule to access the brain during fetal stages it must bypass efflux transporters at both the placental barrier and brain barriers themselves. Following birth, placental protection is no longer present and brain barriers remain the major line of defense. Understanding developmental differences that exist in the transfer of PGP substrates into the brain is important for ensuring that medication regimes ..View full abstract
Awarded by CASS Foundation, Victoria, Australia
This work was supported by the CASS Foundation, Victoria, Australia . The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.