Journal article

Control of Gene Expression by Exosome-Derived Non-Coding RNAs in Cancer Angiogenesis and Lymphangiogenesis

Valeria Arcucci, Steven A Stacker, Marc G Achen

BIOMOLECULES | MDPI | Published : 2021

Abstract

Abstract: Tumour angiogenesis and lymphangiogenesis are hallmarks of cancer and have been associated with tumour progression, tumour metastasis and poor patient prognosis. Many factors regulate angiogenesis and lymphangiogenesis in cancer including non-coding RNAs which are a category of RNAs that do not encode proteins and have important regulatory functions at transcriptional and post-transcriptional levels. Non-coding RNAs can be encapsulated in extracellular vesicles called exosomes which are secreted by tumour cells or other cells in the tumour microenvironment and can then be taken up by the endothelial cells of blood vessels and lymphatic vessels. The "delivery" of these non-coding RN..

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by NHMRC


Funding Acknowledgements

S.A.S. was supported by a Program Grant (APP1053535), a Senior Research Fellowship (APP1154746) and an Investigator Grant (APP1176732) from the National Health and Medical Research Council of Australia (NHMRC) and by funds from the Operational Infrastructure Support Program provided by the Victorian Government. MGA was supported by an NHMRC Program Grant (APP1053535) and by a NHMRC Ideas Grant (APP1183926).