Journal article

Insulin resistance in transgender individuals correlates with android fat mass

Ingrid Bretherton, Cassandra Spanos, Shalem Y Leemaqz, Gehan Premaratne, Mathis Grossmann, Jeffrey D Zajac, Ada S Cheung

Therapeutic Advances in Endocrinology and Metabolism | SAGE PUBLICATIONS LTD | Published : 2021

Abstract

Background: Transgender individuals receiving gender-affirming hormone therapy (GAHT) are at increased risk of adverse cardiovascular outcomes. This may be related to effects on body composition and insulin resistance. Aims: To examine relationships between body fat distribution and insulin resistance in transgender individuals on established GAHT. Methods: Comparisons of body composition (dual energy X-ray absorptiometry) and insulin resistance [Homeostasis Model of Insulin Resistance (HOMA2-IR)] were made between transgender individuals (43 trans men and 41 trans women) on established GAHT (>12 months) and age-matched cisgender controls (30 males and 48 females). Multiple linear regression..

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Grants

Awarded by Rowden White Scholarship


Awarded by Australian Government National Health and Medical Research Council Early Career Fellowship


Funding Acknowledgements

The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: IB is supported by an Australian Government Research Training Program Scholarship and a Rowden White Scholarship (#184409), The University of Melbourne. AC is supported by an Australian Government National Health and Medical Research Council Early Career Fellowship (#1143333) and receives research support by the Viertel Charitable Foundation Clinical Investigator Award, Endocrine Society of Australia Postdoctoral Award, Austin Medical Research Foundation and the Royal Australasian College of Physicians Vincent Fairfax Family Foundation.