Journal article

Childhood vaccination and allergy: A systematic review and meta-analysis

Samidi Navaratna, Marie J Estcourt, John Burgess, Nilakshi Waidyatillake, Elizabeth Enoh, Adrian J Lowe, Rachel Peters, Jennifer Koplin, Shyamali C Dhamage, Caroline J Lodge

ALLERGY | WILEY | Published : 2021

Abstract

BACKGROUND AND OBJECTIVE: As the rise in prevalence of allergic diseases worldwide corresponds in time with increasing infant vaccination, it has been hypothesized that childhood vaccination may increase the risk of allergic disease. We aimed to synthesize the literature on the association between childhood vaccination and allergy. DESIGN: We searched the electronic databases PubMed and EMBASE (January 1946-January 2018) using vaccination and allergy terms. METHODS: Two authors selected papers according to the inclusion criteria. Pooled effects across studies were estimated using random-effects meta-analysis. Due to inadequate number of homogeneous publications on newer and underused vaccine..

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